The active ingredient in magic mushrooms, psilocybin, has been used in a clinical trial as an antidepressant.
The science of antidepressants, is not, as it goes, an exact science. Two patients can react differently to the same drug. For some people, many of the existing drugs won’t have any effect at all.
Science is still struggling to work out why certain drugs only work for certain people. According to one study from Chicago’s Northwestern University, doctors treat the causes in a crude way, with drugs “aimed at the wrong target,” often focusing on reducing stress rather than depression itself. Others have suggested that commercial interests are skewing results when antidepressants are being tested. A study in the New England Journal of Medicine found that some drug companies were selectively publishing studies on antidepressants which showed the drugs had a benefit, and shelving others which showed there was no overall effect.
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